bcaas voorkomen proteine afbraak, m

bcaas voorkomen proteine afbraak, maar verhogen de proteine synthese niet
-Since 1978 a variety of studies have been performed in humans where BCAAs or leucine alone was administrated in varying amounts and durations. An anabolic effect of leucine and the branched-chain amino acids (BCAAs) on reduction of muscle protein breakdown was found in these studies, with no measured effect upon muscle protein synthesis. In addition, no untoward effects have been reported in any of these studies from infusion of the BCAAs at upward 3 times basal flux or 6 times normal dietary intake during the fed portion of the day (B1).
-BCAA infusion in 10 postabsorptive normal subjects causes a 4-fold rise in arterial BCAA levels. Plasma insulin levels were unchanged from basal levels. Whole-body phenylalanine flux, an index of proteolysis, was significantly suppressed by BCAA infusion. Despite the rise in whole-body non-oxidative leucine disposal, and in forearm leucine uptake and disposal, forearm phenylalanine disposal, an index of muscle protein synthesis, was not stimulated by infusion of branched-chain amino acids (B2).
-BCAAs during 1h cycle exercise and a 2h recovery period does not influence the rate of exchange of the aromatic AAs during exercise. In the recovery period, a faster decrease in the muscle concentration of aromatic AAs was found (46% compared with 25% in the placebo condition). There was also a tendency to a smaller release (an average of 32%) of these amino acids from the legs. The results suggest that BCAA have a protein-sparing effect during the recovery after exercise (E5)
-7.5-12 g BCAAs during intense exercise (a 30 km cross-country race and a full marathon) increases BCAA plasma and muscle concentration. In the placebo group plasma BCAA decreased and left muscle levels unchanged. The placebo group showed a 20-40% increase in the muscle concentration of aromatic AAs. BCAA supplementation prevented this increase in aromatic AAs in both muscle and plasma. These results suggest that an intake of BCAAs during exercise can prevent or decrease the net rate of protein degradation caused by heavy exercise (E8).
-77 mg BCAAs/kg supplementation before exercise resulted in a doubling (P < 0.05) of the arterial BCAA levels before exercise (339 +/- 15 vs. 822 +/- 86 microM). During the 60 min of exercise, the total release of BCAA was 68 +/- 93 vs. 816 +/- 198 mumol/kg (P < 0.05) for the BCAA and control trials, respectively. Furthermore, the increased intramuscular and arterial BCAA levels before and during exercise result in a suppression of endogenous muscle protein breakdown during exercise.(E105).

Help bij vetverbranding tijdens cutten
-BCAA supplementation (76% leucine) in combination with moderate energy restriction has been shown to induce significant and preferential losses of visceral adipose tissue and to allow maintenance of a high level of performance (E14).
-In adipocytes from fed rats, the rate of fatty acid synthesis in the presence of glucose and insulin was inhibited 40% by valine (5 mm) (E4).
-Twenty-five competitive wrestlers restricted their caloric intake (28 kcal.kg-1.day-1) for 19 days. A high-BCAA diet provided 4 kg of weight loss, and 17,3% decrease in fat loss. There was no change in aerobic (VO2max) (p > 0.75) and anaerobic capacities (Wingate test) (p > 0.81), and in muscular strength (p > 0.82). (E7).

Voorkomen afname van glutamine
-Following an exercise bout, a decrease in plasma glutamine concentration can be observed, which is completely abolished by BCAA supplementation (G12).
-BCAA supplementation during a triathlon completely prevents the decrease in plasma glutamine (G13).

Voorkomen voor een deel spierschade tijdens training
-We hypothesized that BCAA supplementation would reduce the serum activities of intramuscular enzymes associated with muscle damage. 120 minutes exercise on a cycle ergometer significantly increases serum creatine kinase (CK) and lactate dehydrogenase (LDH) up to 5d postexercise.
12 g BCAAs for 14d in 16 men (the exercise on day 7) significantly reduces this change in LDH and CK (B3).

WAAROM ESSENTIELE AMINOZUREN (EAAs) VOOR HERSTEL:
A) EAAs verhogen proteine synthese boven basale waarden.
B) Voorkomen van spierpijn

1)Niet-essentiele aminozuren zijn niet nodig voor stimuleren van de netto spier-proteine balans (6 g EAAs geven een 2 x zo sterk resultaat als 3 g EAAs en 3 g niet-essentiele aminozuren) (E12).
2)40 g EAAs verhogen de proteine balans niet meer dan 20 g EAAs (E15).
3)Inname van orale EAAs veroorzaken een verandering van netto spier proteine afbraak naar netto spier proteine synthese na zware krachttraining in mensen vergelijkbaar met EAAs supplementatie via een infuus (E15).

EAAs verhogen proteine synthese boven basale waarden
-EEAs (essential amino acids) increases net muscle protein balance. 2 x 6 g provides double the response of 2 x 3 g (E12).
-Consumption of 40 g EAAs after heavy resistance training results in a change from net protein degradation (-50 +/- 23 nmol. min-1. 100 ml leg volume-1) to net protein synthesis (29 +/- 14 nmol. min-1. 100 ml leg volume-1; P < 0.05) (E15).
-A 0.15 g/kg/h AA infusion for 3 h in 6 normal men increases muscle protein synthesis by 141%. After exerecise this increase is 291%. Muscle protein breakdown was not significantly affected (E23).
-Consumption of 6 g EAA + 35 g sucrose immediately before exercise elevates response of net muscle protein synthesis more than consumption following exercise. Total net phenylalanine uptake across the leg was greater (P = 0.0002) during PRE (209 * 42 mg) than during POST (81 * 19) (E102).
-6 g amino acids consumed at 1 and 2 h after resistance exercise increases protein synthesis (total net uptake of phenylalanine across the leg) (71 +/- 13 mg x leg x 3h). Prior intake of amino acids and carbohydrate does not diminish the metabolic response to a second comparable dose ingested 1h later (K24).

Voorkomen van spierpijn
-3.6 g AAs before and after exercise + 2 doses/d for 4 d after the exercise suppresses the rise in serum creatine kin

Results (Croatian) 1:

BCAA spriječi razgradnju proteina, ali ne povećava sintezu proteina
-od 1978 različitih studija su ormed kod ljudi kojima BCAA ili leucin sama je obrađena u različitim količinama i trajanja. anabolički učinak leucin i razgranatog lanca aminokiselina (BCAA) na smanjenje mišićne razgradnje proteina pronađen je u studijama teze,Mjereno bez učinka na sintezu proteina u mišićima. Osim toga, nema untoward učinci su zabilježeni u bilo studija ili teze iz infuzije od BCAA na gore tri puta bazalnih toka ili šest puta normalne unosu tijekom hranjenih dio dana (B1).
-BCAA infuziju u 10. normalnom postabsorptive Ispitanici uzrokuje četverostruki porast arterijskog BCAA razinama.plazmi razina inzulina bila nepromijenjena u odnosu na bazalnim razinama. cijelo tijelo fenilalanin toka, indeks proteolize, Znakovito je potisnuti BCAA infuzije. unatoč porastu u cijelo tijelo ne oksidativnog leucine raspolaganju, a podlaktice leucin upijanje i odlaganje, podlaktice fenilalanin smeća, indeks mišića sintezu proteina,nije potaknuto priljevom razgranatog lanca aminokiselina (B2).
-BCAA tijekom 1h ciklusa vježbanja i razdoblje 2h oporavka ne utječe na tečaj od aromatskog mamac za vrijeme vježbanja. u razdoblju oporavka, brži pad u mišićima koncentracije aromatičnog mamac je pronađen (46% u usporedbi s 25% u placebo stanju).korisno je tendencija u manjem izdanju (prosječno 32%) ili teza aminokiselina iz nogu. Rezultati pokazuju da su BCAA proteina štede snagu tijekom oporavka nakon vježbanja (E5)
-7.5-12 g BCAA tijekom intenzivnog vježbanja (30 km cross-country utrka i puna maraton) povećava BCAA plazme i mišića koncentraciju.u placebo skupini plazma razine BCAA Smanjena mišića i ostao je nepromijenjen. placebo skupina pokazala je da povećavaju 20-40% u mišićima koncentracije aromatičnog mamac. BCAA nosa tome spriječio da povećavaju u aromatičnom mamac u oba mišića i plazme.Ta teza rezultati upućuju na uzimanje BCAA za vrijeme vježbe mogu spriječiti ili smanjiti neto stopu razgradnje proteina uzrokovane napornog vježbanja (E8).
-77 Mg / kg BCAA nosa prije vježbanja rezultiralo udvostručenjem (p <0,05) od arterijske BCAA razine prije vježbanja (339 / - 15 vs 822 / -. 86 microM). tijekom 60 minuta vježbanja, ukupno izdanje BCAA je 68 / - 93 vs816 / - 198 mumol / kg (p <0,05) za bcaa i kontrolu suđenja, respektivno. Nadalje, povećane intramuskularna i arterijske krvi BCAA prije i tijekom vježbanja rezultiralo suzbijanje endogenog sloma mišića proteina tijekom vježbanja. (E105).


Pomoć u sagorijevanje masti, a rezanje-BCAA nosa (76% leucin) izazivaju u kombinaciji s umjerenom energije ograničenja ima nogu pokazala da značajno i povlaštena gubitaka visceralnog masnog tkiva, a kako bi se omogućilo održavanje visoke razine izvedbe (E14).
-U adipocytes iz hranjenih štakora, u stopa sinteze masnih kiselina u prisutnosti glukoze i inzulina je inhibira 40% valina (5 mm) (e4).
-Dvadeset i pet natjecateljski hrvači ograničiti njihov unos kalorija (28 kcal.kg-1.Day-1) za 19 dana. high-BCAA prehrana uvjetom 4 kg mršavljenja, a 17,3% manje u gubitak masnoće. nije bilo promjena u aerobic (VO2max) (p> 0,75) i anaerobnog kapaciteta (Wingate test) (p> 0,81), au mišićne snage (p> 0,82). (E7).


Spriječiti pad glutamina-sljedeći nastup vježbe,Smanjenje koncentracije u plazmi glutamina može promatrati, koji je u potpunosti ukinuti do BCAA nosa (G12).
-BCAA nosa u triatlonu spriječava pad u plazmi glutamina (G13).

dogodi neko oštećenja mišića tijekom treninga
-To smo pretpostavili BCAA nosa bi smanjili serum aktivnosti intramuskularnim enzima povezanih s oštećenja mišića. 120 minuta vježbanja na ergometru ciklusa značajno povećava serum kreatin kinaze (CK) i laktat dehidrogenaze (LDH) do 5D postexercise.
12 g BCAA za 14D u 16 muškaraca (vježba na dan 7.) značajno smanjuje ovu promjenu u LDH i CK (B3).

Zato esencijalne aminokiseline (EAAs) za oporavak:
) EAAs povećanje sinteze proteina iznad bazalne vrijednosti
b) spriječiti bol u mišićima

1) non-esencijalne aminokiseline nisu potrebne za stimulaciju neto ravnoteže mišića proteina (6 g EAAs. dati 2 x kao što su snažnim rezultatima 3 g 3 g EAAs i ne-esencijalnih aminokiselina) (E12).
2) 40 g proteina EAAs povećanje bilanca ne prelazi 20 g EAAs (E15).
3) uzimanje oralnih EAAs uzrokovati promjenu neto razgradnje mišićnog proteina na neto sintezu mišićnog proteina nakon teških treninga snage u ljude slične EAAs nosa kroz drip (E15).

EAAs povećanje sinteze proteina iznad bazalne vrijednosti
-EEAS (bitna aminokiseline) Povećava neto ravnotežu mišićnog proteina. 2 x 6 g Pruža dvostruko odgovor ili 2 x 3 g (E12).
-Potrošnja 40 g EAAs nakon jakih rezultata otpor trening u promjenu od neto razgradnju proteina (-50 / - 23 nmol min-1 100 ml nogu volume 1. ..) u odnosu na neto sintezu proteina (29/14 -. Nmol min- . nogu volumen od 1 100 ml-1, p <0,05) (E15)
-0:15 g / kg / hr AA infuzije za 3 sata u jednoj normalnoj 6. Povećava sintezu proteina u mišićima od 141% .. Nakon exerecise to da povećavaju se 291%.mišićnog proteina kvar nije bio značajno affectedness (E23).
-potrošnju ili 6 g EAA 35 g saharoze Neposredno prije vježbanja povećava odgovor neto sintezu mišićnog proteina više od potrošnje nakon vježbanja. Ukupna neto fenilalanin upijanje preko nogu bila je veća (p = 0,0002) u predsezoni (209 * 42 mg) nego tijekom post (81 * 19) (E102).
-6 G aminokiselina Potrošeno na 1 i 2 h nakon otpora vježbe Povećava sintezu proteina (ukupni neto upijanje fenilalanin preko nogu) (71 / - 13 mg x nogu x 3h). Prije unos aminokiselina i ugljikohidrata ne umanjuje metabolički odgovor na drugi usporedivi doze ingestirale 1h kasnije (K24).


-3 Spriječava bol u mišićima.6 g mamac prije i poslije vježbanja 2 doze / D za 4 D nakon vježbanja suzbija rast u serumu kreatin bradi